Demaryius Thomas - WR - New England Patriots
New York Jets WR Demaryius Thomas (hamstring) aggravated his hamstring injury in Week 2 against the Cleveland Browns and he will not return.
Huddle Up: Thomas is clearly not 100 percent, was rushed into action and he is now hurt. Avoid him in all fantasy leagues until he can return to health, get familiar with the playbook and show a little consistency.
Odell Beckham - WR - Cleveland Browns
Cleveland Browns WR Odell Beckham Jr. (lower leg) suffered an apparent lower leg injury late in the second quarter after landing awkwardly in the end zone in Week 2 against the New York Jets. He attempted to get up, couldn't walk, and went back down to his backside. He then jogged off to meet with the training staff before trotting to the locker room right before halftime.
Huddle Up: Beckham looked to be in obvious discomfort initially, but he ran rather briskly into the locker room on third and long, suggesting he might be OK to begin the second half. We'll keep an eye on it.
David Njoku - TE - Cleveland Browns
Updating a previous report, Cleveland Browns TE David Njoku (concussion) suffered a concussion in the first quarter of the Week 2 game against the New York Jets and he will not return.
Huddle Up: Njoku was upended on a pass play and landed awkwardly after having his legs taken out, hitting his head on the field turf surface. Demetrius Harris, Ricky Seal-Jones and Pharaoh Brown are the next men up at the position, with Harris likely to see the most targets.
Trevor Siemian - QB - Minnesota Vikings
New York Jets QB Trevor Siemian (leg) was hit in the second quarter of the Week 2 game against the Cleveland Browns and it appeared he suffered a lower leg injury. The telecast immediately cut away after the replay which showed the gruesome injury.
Huddle Up: Siemian was started in place of Sam Darnold (mononucleosis), and he didn't even last until halftime. The Jets will now turn to Luke Falk, the sixth-round pick of the Tennessee Titans in 2018, takes over under center. Siemian was able to walk off gingerly to the locker room with the help of the training staff.
David Njoku - TE - Cleveland Browns
Cleveland Browns TE David Njoku (head) left the Week 2 game early and is being evaluated for a concussion.
Huddle Up: Njoku will need to be medically cleared before he can play again, so he may not return to the game. He can be considered a low-end No. 1 tight end when he is healthy.
David Johnson - RB - Arizona Cardinals
Arizona Cardinals RB David Johnson (wrist) will be available to play in the Week 3 game despite the wrist injury he suffered in Week 2, according to head coach Kliff Kingsbury.
Huddle Up: Johnson was held to only 14 total yards in the Week 2 game but should be more involved in the offense this week. Fantasy players in all leagues should have Johnson in their starting lineups.
Drew Brees - QB - New Orleans Saints
New Orleans Saints QB Drew Brees (thumb) said he is scheduled to meet with a specialist Tuesday, Sept. 17, and will make a decision in the near future.
Huddle Up: Brees is expected to miss at least six weeks because of the thumb injury, but fantasy players may want to wait for an official timetable for making any decisions. Teddy Bridgewater will take over the starting job while Brees is sidelined but may only be a No. 2 fantasy quarterback.
Sterling Shepard - WR - New York Giants
New York Giants WR Sterling Shepard (concussion) is still going through the concussion protocol but has been cleared to practice in a non-contact jersey.
Huddle Up: Shepard needs to be cleared by doctors before he is allowed to play, so fantasy players should monitor his practice participation this week. He is the team's top receiver when he is healthy but may only be a No. 3 fantasy receiver or flex option when he returns.
Demaryius Thomas - WR - New England Patriots
New York Jets WR Demaryius Thomas (hamstring) is officially active for the team's Week 2 game.
Huddle Up: Thomas joined the team last week and missed all three practices leading up to the game, so it is not known how he will be used in the passing game. Fantasy players may want to see him play first before considering him a starting option.
Le'Veon Bell - RB - New York Jets
New York Jets RB Le'Veon Bell (shoulder) is officially active for the team's Week 2 game.
Huddle Up: Bell should receive plenty of touches this week with Sam Darnold sidelined and is a must-start option in all fantasy leagues.
Ben Roethlisberger - QB - Pittsburgh Steelers
Pittsburgh Steelers QB Ben Roethlisberger (elbow) said he plans to play again after he recovers from his elbow surgery.
Huddle Up: It is not known how long Roethlisberger will be sidelined, so it is a question if he will be ready for the 2020 season opener. Mason Rudolph will be the starting quarterback for the rest of this season but probably is only a No. 2 quarterback in deeper leagues.
Alshon Jeffery - WR - Philadelphia Eagles
Philadelphia Eagles WR Alshon Jeffery (calf) is dealing with a calf strain and his status for the next two games are uncertain. The injury is not considered serious, but the team plays two games in 10 days.
Huddle Up: Fantasy players will need to monitor the situation to see if Jeffery misses any games. He is a solid starting option when he is healthy, but players should have other options ready in case he misses time.
James Conner - RB - Pittsburgh Steelers
Pittsburgh Steelers RB James Conner (knee) said he expects to play in Week 3 and that he does not have any tears or serious problems in his knee.
Huddle Up: Conner probably will be limited during practice this week, so fantasy players should check on his status later this week. He has struggled during the first two weeks of the season but could receive more touches with Ben Roethlisberger sidelined. Conner should still be a starting option in all leagues.
Devin Singletary - RB - Buffalo Bills
Buffalo Bills RB Devin Singletary (hamstring) is considered day-to-day because of the hamstring injury he suffered in Week 2.
Huddle Up: Fantasy owners should check on Singletary's status later in the week to see if he is in any danger of missing Week 3. He has played well even though he is not the starting running back and could be a flex option this week if he plays.
A.J. Brown - WR - Tennessee Titans
Tennessee Titans WR A.J. Brown (knee) was limited during practice Monday, Sept. 16. The Titans did not hold a practice Monday, so this is an estimation.
Huddle Up: Brown had a disappointing Week 2 performance after his 100-yard game in Week 1. He has been targeted nine times over the first two games and likely will receive a similar workload if he plays in Week 3. He is not a must-start option but could be used in some deeper leagues.
Marcus Mariota - QB - Tennessee Titans
Tennessee Titans QB Marcus Mariota (quadriceps) did not participate in practice Monday, Sept. 16. The Titans did not hold a practice Monday, so this is an estimation.
Huddle Up: Fantasy players will know more about Mariota's status over the next few days. He has thrown for 402 yards and four touchdowns in the first two games but will be facing a solid Jacksonville Jaguars defense this week and could be benched if players have better options.
Tyrell Williams - WR - Oakland Raiders
Oakland Raiders WR Tyrell Williams (hip) is dealing with a hip pointer, according to head coach Jon Gruden.
Huddle Up: Williams did see a drop in his production in Week 2 after a strong opener but was able to catch a touchdown pass for the second straight week. He will be facing a solid Minnesota Vikings defense this week but could still be a No. 3 receiver or flex option.
Josh Jacobs - RB - Oakland Raiders
Oakland Raiders RB Josh Jacobs (groin) is dealing with a groin injury, according to head coach Jon Gruden.
Huddle Up: Fantasy players will need to monitor the situation during the week to see if Jacobs will be able to play in Week 3. He has rushed for 184 yards over the first two games and would be a starting option in all leagues if he is able to play.
Chris Conley - WR - Jacksonville Jaguars
Jacksonville Jaguars WR Chris Conley (hip) was limited during practice Monday, Sept. 16. The Jaguars did not hold a practice Monday, so this is an estimation.
Huddle Up: Conley is off to a solid start to the season with 170 yards and one touchdown. He has caught 10 of his 12 targets this season and appears to have a good connection with Gardner Minshew. Fantasy players in deeper leagues could consider Conley as a possible flex option.
Marqise Lee - WR - Jacksonville Jaguars
Jacksonville Jaguars WR Marqise Lee (knee) was limited during practice Monday, Sept. 16. The Jaguars did not hold a practice Monday, so this is an estimation.
Huddle Up: Lee did not play in Week 2, so his status for Week 3 is still to be determined. Fantasy players likely will be able to find better options to use and can keep Lee on the bench.