Andre Ellington - RB - Arizona Cardinals
Arizona Cardinals RB Andre Ellington (quadriceps) is not expected to play against the Los Angeles Rams in Week 7, according to a source.
Huddle Up: Ellington's absence should ensure that Adrian Peterson dominates the backfield touches for the second week in a row, and he can be deployed as a RB2 against the Rams.
Jordan Howard - RB - Chicago Bears
Chicago Bears RB Jordan Howard has rushed a combined 55 times for 243 yards in the two games QB Mitchell Trubisky has started.
Huddle Up: After an uneven start to the year, Howard has resumed his role as a workhorse back. Having Trubisky at quarterback should ensure that the Bears continue to lean on Howard going forward. Consider him a volume-based RB2 against a solid Carolina Panthers defense in Week 7.
Todd Gurley - RB - Los Angeles Rams
Los Angeles Rams RB Todd Gurley faces the Arizona Cardinals in London in Week 7, and he said the NFL needs to stop overseas games.
Huddle Up: Gurley might be unhappy with the lengthy travel, but that shouldn't stop him from producing. He has rushed for more 100 yards in three of his last four games, and he has delivered at least 96 yards from scrimmage in five of his six games this year. Plug him in as a RB1.
Leonard Fournette - RB - Jacksonville Jaguars
Jacksonville Jaguars RB Leonard Fournette (ankle) is not expected to play against the Indianapolis Colts in Week 7, according to a source.
Huddle Up: With Fournette expected to be sidelined, Chris Ivory becomes a low-end RB2 candidate against the Colts.
Kareem Hunt - RB - Kansas City Chiefs
Kansas City Chiefs RB Kareem Hunt is the only player in NFL history to gain 100 or more yards from scrimmage in each of his first seven games.
Huddle Up: Not only does Hunt lead the league in rushing, but his sizeable role in the passing game allows him to remain a weapon no matter the score and pace of play. He will be a must-start RB1 when the Chiefs face the Denver Broncos in Week 8.
Emmanuel Sanders - WR - Denver Broncos
Denver Broncos WR Bennie Fowler is expected to serve as the No. 2 receiver against the Los Angeles Chargers in Week 7 with WR Emmanuel Sanders (ankle) sidelined.
Huddle Up: Fowler saw a season-high eight targets when Sanders exited in Week 6, and he could be a sneaky WR3 or flex play against the Chargers.
Michael Floyd - WR - Minnesota Vikings
Minnesota Vikings WR Michael Floyd (hamstring) is listed as questionable for Week 7 but said he is optimistic about his chances of playing. Floyd also said he would like to see more targets in the passing game.
Huddle Up: Floyd has recorded two catches and 24 yards in two games this season and has been targeted four times during that span. He could receive some more playing time this week with Stefon Diggs sidelined but should be avoided in fantasy leagues.
Wendell Smallwood - RB - Philadelphia Eagles
Philadelphia Eagles RB Wendell Smallwood (knee) fully participated in practice Saturday, Oct. 21, and is listed as questionable for Week 7.
Huddle Up: Smallwood was a full participant during practice this week, so he should have a good chance to play in Week 7. He will receive a limited amount of touches if he plays but could still be a flex option in some leagues.
Rob Kelley - RB - Washington Redskins
Washington Redskins RB Rob Kelley (ribs) was limited during practice Saturday, Oct. 21, and is listed as questionable for Week 7.
Huddle Up: Kelley is expected to play against the Philadelphia Eagles but will share work with Samaje Perine and Chris Thompson during the game. Owners probably should keep Kelley off the bench because there likely are other options available that will receive more work this week.
Charles Clay - TE - Buffalo Bills
Buffalo Bills head coach Sean McDermott is optimistic that TE Charles Clay (knee) could resume playing before the end of the season.
Huddle Up: Clay is recovering from arthroscopic knee surgery to repair a torn meniscus and sprained medial collateral ligament suffered in Week 5's game against the Cincinnati Bengals. Nick O'Leary will continue to start in place of Clay but fantasy owners should be able to find better options.
Sam Bradford - QB - Minnesota Vikings
Minnesota Vikings head coach Mike Zimmer believes QB Sam Bradford (knee) will be able to resume playing later this season.
Huddle Up: Bradford was ruled out for Week 7's game versus the Baltimore Ravens after not practicing at all during the week and no official timetable has been established for his return. Case Keenum will continue to serve as the Vikings' starter in his absence but only has value in two-quarterback leagues or as a possible bye-week replacement.
Antonio Gates - TE - Los Angeles Chargers
Los Angeles Chargers TE Hunter Henry has seen 15 targets over the last two games compared to four targets for TE Antonio Gates. Gates was targeted 17 times and Henry 10 times over the first four games.
Huddle Up: Now that Gates has the touchdown record for tight ends, it looks like the Chargers are featuring Henry. He looks like a TE1 going forward.
Isaiah Crowell - RB - Cleveland Browns
Cleveland Browns RB Duke Johnson has outgained RB Isaiah Crowell by 62 total yards on 36 fewer touches, and Johnson leads the team with 26 catches and 269 receiving yards.
Huddle Up: Although Crowell continues to see more carries, Johnson's efficiency and involvement in the passing game make him the better fantasy option and a RB2 in PPR formats against the Tennessee Titans in Week 7.
Zach Ertz - TE - Philadelphia Eagles
Philadelphia Eagles TE Zach Ertz's 53 targets rank eighth in the NFL, and he is the only tight end ranked in the top 10 in targets.
Huddle Up: Ertz has been targeted at least eight times in five of the first six games, and he has topped 50 yards five times. He has emerged as a must-start TE1, and that won't change against the Washington Redskins in Week 7.
Latavius Murray - RB - Minnesota Vikings
Minnesota Vikings RB Latavius Murray is averaging 2.6 yards on 25 carries in the two games since RB Dalvin Cook (knee) was injured.
Huddle Up: Murray has been splitting time with Jerick McKinnon in Cook's absence, but McKinnon has been the more explosive and versatile back. Murray is a low-upside flex play against the Baltimore Ravens in Week 7, and McKinnon has RB2 upside in PPR formats.
Brandin Cooks - WR - New England Patriots
New England Patriots WR Brandin Cooks said he believes he will be able to showcase his explosiveness more often as the season goes on. 'At the end of the day, I just want to stick to the process, perfect my craft and pay attention to the little details,' Cooks said. 'And I feel like it's going to come.'
Huddle Up: Cooks has just two touchdowns this year, but he has still been a big part of the passing game, delivering at least 85 yards in four of the six games. He is locked in as a WR2 heading into a Week 7 matchup against the Atlanta Falcons.
Martavis Bryant - WR - Pittsburgh Steelers
Pittsburgh Steelers WR Martavis Bryant has not been mentioned in trade discussions, according to team president Art Rooney II. 'We're not looking to trade Martavis,' Rooney said. 'He was out of football for a year. Maybe some of us had higher expectations how quickly he could get back up to full speed, but he's making progress.'
Huddle Up: Bryant has been one of the biggest fantasy busts this season. The potential for a big play is still there, but Bryant is a total Hail Mary play at this point.
Tom Brady - QB - New England Patriots
New England Patriots QB Tom Brady said Friday, Oct. 20, that he doesn't feel his accuracy is where it needs to be, especially in the red zone where the Patriots have scored 14 touchdowns in 25 trips.
Huddle Up: For someone who is disappointed in his accuracy, Brady continues to put up QB1 numbers on a weekly basis, and he is a must-start option against the Atlanta Falcons in Week 7.
Chris Thompson - RB - Washington Redskins
Washington Redskins RB Rob Kelley said it 'wouldn't be beneficial' for him to receive all the carries, especially with RB Chris Thompson playing so well. 'Whatever Coach needs, I'm there for,' Kelley said. 'If he wants me to run it the whole time, I can run it the whole time. If he wants to split carries, I can do that, too.'
Huddle Up: Kelley can be left on the bench in Week 7 against the stingy run defense of the Philadelphia Eagles, and although Kelley's return will take some touches from the rest of the backs, Thompson remains a viable flex option in PPR formats.
Aaron Rodgers - QB - Green Bay Packers
Green Bay Packers QB Aaron Rodgers (collarbone) was placed on the Reserve/Injured list, but the team hopes that he will be able to return in time for the team's Week 15 game against the Carolina Panthers, according to a source.
Huddle Up: Rodgers will miss at least eight weeks but has not been ruled out for the season at this point, so owners will need to keep an eye on his recovery. Owners that have roster space could consider stashing Rodgers on the bench, but he can be dropped if owners need the space.